Stem Cell Therapy: A Future Treatment of Stress Urinary Incontinence

Dmitriy Nikolavasky; Klaudia Stangel-Wójcikiewicz; Malgorzata Stec; Michael B Chancellor

doi:10.1055/s-0030-1268705

Seminars in Reproductive Medicine, Table of Contents

Semin Reprod Med 2011; 29(1): 061-070
DOI: 10.1055/s-0030-1268705

Stem Cell Therapy: A Future Treatment of Stress Urinary Incontinence

Dmitriy Nikolavasky¹ , Klaudia Stangel-Wójcikiewicz² , Malgorzata Stec² , Michael B. Chancellor¹

¹Department of Urology, William Beaumont Hospital, Royal Oak, Michigan
²Department of Gynecology and Transplantology, Collegium Medicum Jagiellonian University of Kraków, Poland

Abstract

ABSTRACT

The main urinary continence mechanism in human is the striated muscle rhabdosphincter that forms a ring around the mid-urethra. Cellular therapy and the use of stem cells transplanted into the site of the rhabdosphincter in a setting of stress urinary incontinence (SUI) may augment sphincter regeneration. Implanted cells may also release trophic factors promoting muscle and nerve integration into this muscle. We review the use of cellular therapy for SUI and our experience with the development of muscle-derived stem cells.

KEYWORDS

Stress urinary incontinence - muscle-derived stem cells - stem cell therapy

Full Text

References

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Michael B ChancellorM.D.

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